Leeper Group
   

Publications

175Alex H. Y. Chan, Terence C. S. Ho, Imam Fathoni, Rawia Hamid, Anna K. H. Hirsch, Kevin J. Saliba and Finian J. Leeper
"Evaluation of Ketoclomazone and its Analogues as Inhibitors of 1-Deoxy-D-Xylulose 5-Phosphate Synthases and Other Thiamine Diphosphate (ThDP)-dependent Enzymes"
RSC Med. Chem., 2024, , in press. Abstract, Full text
174Alex H. Y. Chan, Terence C. S. Ho and Finian J. Leeper
"Thiamine Analogues featuring Amino-oxetanes as Potent and Selective Inhibitors of Pyruvate Dehydrogenase"
Bioorg. Med. Chem. Lett., 2024, 98, 129571. Abstract, Full text
173Alex H. Y. Chan, Terence C. S. Ho and Finian J. Leeper
"Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes"
Org. Biomol. Chem., 2023, 21, 6531-6536. Abstract, Full text
172Alex H. Y. Chan, Terence C. S. Ho, Rimsha Irfan, Rawia A. A. Hamid, Emma S. Rudge, Amjid Iqbal, Alex Turner, Anna K. H. Hirsch and Finian J. Leeper
"Design of Thiamine Analogues for Inhibition of Thiamine Diphosphate(ThDP)-dependent Enzymes: Systematic Investigation through Scaffold-Hopping and C2-Functionalisation"
Bioorg. Chem., 2023, 138, 106602. Abstract, Full text
171Alex H. Y. Chan, Terence C. S. Ho, Imam Fathoni, Rebecca Pope, Kevin J. Saliba and Finian J. Leeper
"Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues"
ACS Med. Chem. Lett., 2023, 14 (5), 621–628. Abstract, Full text
170Annabel C. Murphy, Matthew Corney, Rita E. Monson, Miguel A. Matilla, George P. C. Salmond and Finian J. Leeper
"Biosynthesis of Antifungal Solanimycin May Involve an Iterative Non-Ribosomal Peptide Synthetase (NRPS) Module"
ACS Chem. Biol., 2023, 18 (5), 1148–1157. Abstract, Full text
169Flaviu Bulat, Friederike Hesse, Bala Attili, Chandra Solanki, Iosif Mendichovszky, Franklin Aigbirhio, Finian J. Leeper, Kevin M. Brindle and André A. Neves
"Preclinical PET Imaging of Tumor Cell Death following Therapy Using Gallium-68-Labeled C2Am"
Cancers, 2023, 15, 1564. Abstract, Full text
168Alex H. Y. Chan, Terence C. S. Ho, Daniel R. Parle and Finian J. Leeper,
"Furan-based inhibitors of pyruvate dehydrogenase: SAR study, biochemical evaluation and computational analysis"
Org. Biomol. Chem., 2023, 21 (8), 1755-1763. Abstract, Full text
167Alex H. Y. Chan, Terence C. S. Ho, Kwasi Agyei-Owusu and Finian J. Leeper,
"Synthesis of pyrrothiamine, a novel thiamine analogue, and evaluation of derivatives as potent and selective inhibitors of pyruvate dehydrogenase"
Org. Biomol. Chem., 2022, 20 (45), 8855–8858. Abstract, Full text
166Miguel A. Matilla*, Rita E. Monson, Annabel Murphy, Muriel Schicketanz, Alison Rawlinson, Caia Duncan, Juan Mata, Finian J. Leeper, George P. C. Salmond*
"Solanimycin: Biosynthesis and Distribution of a New Antifungal Antibiotic Regulated by Two Quorum-Sensing Systems"
mBio, 2022, 13 (6), 02472-22. Abstract, Full text
165 Oksana Bilyk*, Gabriel S. Oliveira, Rafaela M. de Angelo, Michell O. Almeida, Kathia Maria Honório, Finian J. Leeper, Marcio V. B. Dias*, and Peter F. Leadlay
"Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis"
J. Am. Chem. Soc., 2022, 144 (32), 14555-14563. Abstract, Full text
164 Daniel R. Parle, Flaviu Bulat, Shahd Fouad, Heather Zecchini, Kevin M. Brindle, André A. Neves, and Finian J. Leeper*
"Metabolic Glycan Labeling of Cancer Cells Using Variably Acetylated Monosaccharides"
Bioconjug. Chem., 2022, 33 (8), 1467-1473. Abstract, Full text
163 Alex H. Y. Chan, Imam Fathoni, Terence C. S. Ho, Kevin J. Saliba and Finian J. Leeper*
"Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity"
RSC Med. Chem., 2022, 13 (7), 817-821. Abstract, Full text
162Emma S. Rudge, Alex H. Y. Chan and Finian J. Leeper*
"Prodrugs of Pyrophosphates and Bisphosphonates: Disguising Phosphorus Oxyanions"
RSC Med. Chem., 2022, 13 (4), 375-391. Abstract, Full text
161Sicong Li, Priscila Dos Santos Bury, Fanglu Huang, Junhong Guo, Guo Sun, Anna Reva, Chuan Huang, Xinyun Jian, Yuan Li, Jiahai Zhou, Zixin Deng, Finian J. Leeper*, Peter F. Leadlay*, Marcio V. B. Dias*, and Yuhui Sun*
"Mechanistic Insights into Dideoxygenation in Gentamicin Biosynthesis"
ACS Catalysis, 2020, 11 (19), 12274-12283. Abstract, Full text
160Finian J. Leeper and Anthony G. Coyne
"Chris Abell 1957–2020"
Biochemist, 2021, 43 (1), 45. Full text
159Maxime Couturier, Hiral D. Bhalara, Rita E. Monson, George P. C. Salmond and Finian J. Leeper
"Revision in the first steps of the biosynthesis of the red antibiotic prodigiosin: use of a synthetic thioester to validate a new intermediate"
RSC Chem. Biol., 2021, 2 (2), 551-555. Abstract, Full text
158 Flaviu Bulat, Friederike Hesse, De-En Hu, Susana Ros, Connor Willminton-Holmes, Bangwen Xie, Bala Attili, Dmitry Soloviev, Franklin Aigbirhio, Finian. J. Leeper, Kevin M. Brindle and André A. Neves
"18F-C2Am: a targeted imaging agent for detecting tumor cell death in vivo using positron emission tomography"
EJNMMI Res., 2020, 10, art. no. 151. Abstract, Full text
157Rory Little, Fernanda C. R. Paiva, Robert Jenkins, Hui Hong, Yuhui Sun, Yuliya Demydchuk, Markiyan Samborskyy, Manuela Tosin, Finian J. Leeper, Marcio V. B. Dias & Peter F. Leadlay
"Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis"
Nature Catalysis, 2019, 2 (11), 1045–1054. Abstract, Full text
156Maxime Couturier, Hiral D. Bhalara, Suresh R. Chawrai, Rita Monson, Neil R. Williamson, George P. C. Salmond and Finian J. Leeper,
"Substrate flexibility of the flavin-dependent dihydropyrrole oxidases PigB and HapB involved in antibiotic prodigiosin biosynthesis"
ChemBioChem, 2020, 21, 523-530. Abstract, Full text
155S. A. Goussous, M. T. L. Casford, A. C. Murphy, G. P. C. Salmond, Finian J. Leeper, and P. B. Davies,
"Structure of the Fundamental Lipopeptide Surfactin at the Air/Water Interface Investigated by Sum Frequency Generation Spectroscopy"
J. Phys. Chem., 2017, 121, 5072-5077. Abstract, Full text.
154William J. K. Crone, Natalia M. Vior, Javier Santos-Aberturas, Lukas G. Schmitz, Finian J. Leeper, Andrew W. Truman,
"Dissecting Bottromycin Biosynthesis Using Comparative Untargeted Metabolomics"
Angew. Chem. Int. Ed., 2016, 55 (33), 9639–9643. Abstract, Full text.
153André A. Neves, Yéléna A. Wainman, Alan Wright, Mikko I. Kettunen, Tiago B. Rodrigues, Sarah McGuire, De-En Hu, Flaviu Bulat, Simonetta Geninatti Crich, Henning Stöckmann, Finian J. Leeper, and Kevin M. Brindle,
"Imaging glycosylation in vivo using metabolic labeling and MRI"
Angew. Chem. Int. Ed., 2016, 55 (4), 1286-1290. Abstract, Full text.
152T. Masini, B. Lacy, L. Monjas, D. Hawksley, A. R. de Voogd, B. Illarionov, A. Iqbal, F. J. Leeper, M. Fischer, M. Kontoyianni, and A. K. H. Hirsch,
"Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of activity differences of thiamine derivatives as potent inhibitors of two orthologues of DXS"
Org. Biol. Chem., 2015, 13, 11263–11277. Abstract, Full text.
151Miguel A. Matilla, Finian J. Leeper, and George P. Salmond,
"Biosynthesis of the antifungal haterumalide, oocydin A, in Serratia, and its regulation by quorum sensing, RpoS and Hfq"
Environ. Microbiol., 2015, 17 (8), 2993–3008. Abstract, Full Text.
150Amjid Iqbal, El-Habib Sahraoui and Finian J. Leeper,
"Gold(I)-catalysed Synthesis of a Furan Analogue of Thiamine Pyrophosphate"
Beilstein J. Org. Chem., 2014, 10, 2580–2585. Abstract, Full Text.
149Laia Josa-Culleré, Yelena A. Wainman, Kevin M. Brindle and Finian J. Leeper,
"Diazo group as a new chemical reporter for bioorthogonal labelling of biomolecules"
RSC Advances, 2014, 4 (94), 52241-52244. Abstract, Accepted manuscript, Supporting Info, Full Text.
148Elena Kasparyan, Michael Richter, Carola Dresen, Lydia S. Walter, Georg Fuchs, Finian J. Leeper, Tobias Wacker, Susana L. A. Andrade, Geraldine Kolter, Martina Pohl, Michael Müller
"Asymmetric Stetter reactions catalyzed by thiamine diphosphate-dependent enzymes"
Appl. Microbiol. Biotechnol., 2014, 98 (23), 9681-9690. Abstract, Full Text.
147Junhong Guo, Fanglu Huang, Chuan Huang, Xiaobo Duan, Xinyun Jian, Finian J. Leeper, Zixin Deng, Peter F. Leadlay and Yuhui Sun
"Specificity and Promiscuity at the Branch Point in Gentamicin Biosynthesis"
Chem. & Biol., 2014, 21 (5), 608–618. Abstract, Full Text.
146Cheryl A. Kreinbring, Stephen P. Remillard, Paul Hubbard, Heather R. Brodkin, Finian J. Leeper, Dan Hawksley, Elaine Y. Lai, Chandler Fulton, Gregory A. Petsko, and Dagmar Ringe
"Structure of a eukaryotic thiaminase I"
Proc. Natl. Acad. Sci. USA., 2014, 111 (1), 137–142. Abstract, Full Text.
145Yéléna A. Wainman, André A. Neves, Shaun Stairs, Henning Stöckmann, Heather Ireland-Zecchini, Kevin M. Brindle and Finian J. Leeper
"Dual-sugar imaging using isonitrile and azido-based click chemistries"
Org. Biomol. Chem., 2013, 11 (42), 7297-7300. Abstract, Accepted manuscript, Full Text.
144Stefan Lüdtke, Piotr Neumann, Karl M. Erixon, Finian J. Leeper, Ronald Kluger, Ralf Ficner and Kai Tittmann,
"Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate"
Nature Chem., 2013, 5, 762-767. Abstract, Full Text.
143 Finian J. Leeper and James M. Kelly,
"Synthesis of 3,4-Disubstituted Pyrroles. A Review"
Org. Prep. Proc. Int., 2013, 45, 171-210. Abstract, Full Text.
142Andre A. Neves, Henning Stöckmann, Yelena A. Wainman, Joe C-H. Kuo, Sarah Fawcett, Finian J. Leeper and Kevin M. Brindle,
"Imaging cell surface glycosylation in vivo using ‘double click’ chemistry"
Bioconjugate Chem., 2013, 24 (6), 934–941. Abstract, Full Text.
141Shaun Stairs, Andre A. Neves, Henning Stöckmann, Yelena A. Wainman, Heather Ireland-Zecchini, Kevin M. Brindle, and Finian J. Leeper,
"Metabolic Glycan Imaging By Isonitrile-Tetrazine Click Chemistry"
ChemBioChem, 2013, 14 (9), 1063-1067. Abstract, Full Text.
140Maryam Beigi, Sabrina Loschonsky, Patrizia Lehwald, Volker Brecht, Susana L. A. Andrade, Finian J. Leeper, Werner Hummel, and Michael Müller
"a-Hydroxy-b-keto Acid Rearrangement–Decarboxylation: Impact on Thiamine Diphosphate-Dependent Enzymatic Transformations"
Org. Biomol. Chem., 2013, 11 (11), 252-256. Abstract, Full Text.
139Miguel A. Matilla, Henning Stöckmann, Finian J. Leeper and George P.C. Salmond,
"Bacterial biosynthetic gene clusters encoding the anti-cancer haterumalide class of molecules: biogenesis of the broad spectrum antifungal and anti-oomycete compound, oocydin A"
J. Biol. Chem., 2012, 287 (46), 39125-39138. Abstract, Full Text.
138William J. K. Crone, Finian J. Leeper and Andrew W. Truman,
"Identification and characterisation of the gene cluster for the anti-MRSA antibiotic bottromycin: Expanding the biosynthetic diversity of ribosomal peptides"
Chem. Sci., 2012, 3 (12), 3516-3521. Abstract, Full Text.
137Liuhong Chen, Elena Cressina, Neil Dixon, Karl Erixon, Kwasi Agyei-Owusu, Jason Micklefield, Alison G. Smith, Chris Abell and Finian J. Leeper,
"Probing riboswitch–ligand interactions using thiamine pyrrophosphate analogues"
Org. Biomol. Chem., 2012, 10 (30), 5924-5931. Abstract, Full Text.
136Helen L. Evans, Rozanna L. Slade, Laurence Carroll, Graham Smith, Quang-De Nguyen, Lisa Iddon, Nazilla Kamaly, Henning Stöckmann, Finian J. Leeper, Eric O. Aboagye and Alan C. Spivey,
"Copper-free Click – A Promising Tool for Pre-Targeted PET Imaging"
Chem. Comm., 2012, 48 (7), 991-993. Abstract, Full Text, Suppl. Info.
135James M. Kelly and Finian J Leeper,
"Synthesis of 3,4-fused cycloalkanopyrroles by 1,3-dipolar cycloaddition"
Tetrahedron Lett., 2012, 53 (7), 819-821. Abstract, Full Text, Suppl. Info.
134Finian J Leeper, Martin J. Warren, James M. Kelly and Andrew D. Lawrence
"Biosynthesis of Vitamin B12"
in Handbook of Porphyrin Science, eds. Karl M. Kadish, Kevin M. Smith and Roger Guilard, 2012, 25, 1-83. Abstract Contents.
133Suresh R. Chawrai, Neil R. Williamson, Thabo Mahendiran, George P. C. Salmond and Finian J Leeper,
"Characterisation of PigC and HapC, the prodigiosin synthetases from Serratia sp. and Hahella chejuensis with potential for biocatalytic production of anticancer agents"
Chem. Sci., 2012, 3 (2), 447-454. Abstract, Full Text, Suppl. Info.
132Henning Stöckmann, André A. Neves, Shaun Stairs, Kevin M. Brindle and Finian J Leeper,
"Exploring isonitrile-based click chemistry for ligation with biomolecules"
Org. Biomol. Chem., 2011, 9 (21), 7303-7305. Abstract, Full Text, Suppl. Info1. Suppl. Info2.
131Henning Stöckmann, Andre A. Neves, Henry A. Day, Shaun Stairs, Kevin M. Brindle and Finian J Leeper,
"(E,E)-1,5-cyclooctadiene: A small and fast click-chemistry multitalent"
Chem. Comm., 2011, 47 (25), 7203-7205. Abstract, Full Text, Suppl. Info.
130 Elena Cressina, Liuhong Chen, Michael Moulin, Finian J Leeper, Chris Abell and Alison G Smith,
"Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches"
Biochem. Soc. Trans., 2011, 39 (2), 652-7. Abstract, Full Text.
129 Manuela Tosin, Yuliya Demydchuk, James S Parascandolo, Covadonga Blasco Per, Finian J Leeper and Peter F Leadlay,
"In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines"
Chem. Comm., 2011 (12), 3460-2. Abstract, Full Text, Suppl. Info.
128 Henning Stöckmann, Andre A. Neves, Shaun Stairs, Heather Ireland-Zecchini, Kevin M. Brindle and Finian J. Leeper,
“Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells”
Chem. Sci., 2011, 2, 932-936. Abstract, Full Text, Suppl. Info.
127 Andre A. Neves, Henning Stöckmann, Rebecca Harmston, Ellie Pryor, Israt S. Alam, Sarah Fawcett, Heather Ireland-Zecchini, David Y. Lewis, Scott K. Lyons, Finian J. Leeper and Kevin M. Brindle,
“Imaging sialylated glycans in a murine tumor in vivo”
FASEB J., 2011, 25 (8), 2528-2537. Abstract, Full Text, Suppl. Info.
126 Elena Cressina, Liuhong Chen, Chris Abell, Finian J. Leeper and Alison G. Smith,
“Fragment screening against the thiamine pyrophosphate riboswitch thiM”
Chem. Sci., 2011, 2, 157-165. Abstract, Full Text, Suppl. Info.
125 Neil R. Williamson, Suresh Chawrai, Finian J. Leeper and George P. C. Salmond,
“Prodiginines and Their Potential Utility as Proapoptotic Anticancer Agents”
in Emerging Cancer Therapy: Microbial Approaches and Biotechnological Tools, Chapter 15, pp. 333-366, A. Fialho and A. Chakrabarty (Editors), Wiley 2010. Abstract, Full Text.
124 Liuhong Chen, Elena Cressina, Finian J. Leeper, Alison G. Smith and Chris Abell,
“A Fragment-Based Approach to Identifying Ligands for Riboswitches”
ACS Chem. Biol., 2010, 5 (4), 355-358. Abstract, Full Text, Suppl. Info.
123 Xue-yuan Pei, Karl M. Erixon, Ben F. Luisi and Finian J. Leeper
“Structural Insights into the Prereaction State of Pyruvate Decarboxylase from Zymomonas mobilis”,
Biochemistry, 2010, 49 (8), 1727-1736. Abstract, Full Text.
122 Kwasi Agyei-Owusu and Finian J. Leeper,
"Thiamin diphosphate in biological chemistry: analogues of thiamin diphosphate in studies of enzymes and riboswitches",
FEBS J., 2009, 276, 2905–2916. Abstract, Full Text.
121 Xue Yuan Pei, Christopher M. Titman, Rene A.W. Frank, Finian J. Leeper and Ben F. Luisi,
"Snapshots of Catalysis in the E1 Subunit of the Pyruvate Dehydrogenase Multienzyme Complex",
Structure, 2008, 16 (12), 1860-1872. Abstract, Full Text, Suppl. Info.
120 Karl M. Erixon, Chester L. Dabalos and Finian J. Leeper,
"Synthesis and biological evaluation of pyrophosphate mimics of thiamine pyrophosphate based on a triazole scaffold",
Org. Biomolec. Chem., 2008, 6, 3561-3572. Abstract, Full Text.
119 Suresh R. Chawrai, Neil R. Williamson, George P. C. Salmond and Finian J. Leeper,
"Chemoenzymatic synthesis of prodigiosin analogues – exploring the substrate specificity of PigC",
Chem. Commun., 2008, 1862–1864. Abstract, Full Text, Suppl. Info.
118 Catrine L. Berthold, Dörte Gocke, Martin D. Wood, Finian Leeper, Martina Pohl and Gunter Schneider,
"Structure of the branched-chain keto acid decarboxylase (KdcA) from Lactococcus lactis provides insights into the structural basis for the chemoselective and enantioselective carboligation reaction."
Acta Cryst., D 2007, 63 (12), 1217–1224. Abstract, Full Text.
117 Neil R. Williamson, Peter C. Fineran, T. Gristwood, Suresh R. Chawrai, Finian J. Leeper and George P. C. Salmond,
"Anticancer and Immunosuppressive Properties of Bacterial Prodiginines."
Future Microbiology, 2007, 2 (6), 605-618. Abstract, Full Text.
116 Finian J. Leeper and Alison G. Smith,
"Editorial: Vitamins and cofactors—chemistry, biochemistry and biology."
Nat. Prod. Rep., 2007, 24 (5), 923–926. Abstract, Full Text.
115 Wim Versées, Stijn Spaepen, Martin D. H. Wood, Finian J. Leeper, Jos Vanderleyden and Jan Steyaert,
"Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase."
J. Biol. Chem., 2008, 282 (48), 35269-35278. Abstract, Full Text, Suppl. Info.
114 Catrine L. Berthold, Cory G. Toyota, Patricia Moussatche, Martin D. Wood, Finian J. Leeper, Nigel G. J. Richards, Ylva Lindqvist,
"Crystallographic snapshots of oxalyl-CoA decarboxylase give new insights into catalysis by non-oxidative ThDP-dependent decarboxylases."
Structure, 2007, 15 (7), 853-861. Abstract, Full Text.
113 Karl M. Erixon, Chester L. Dabalos and Finian Leeper,
"Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics."
Chem. Comm., 2007, 960-962. Abstract, Full Text, Suppl. Info.
112 René Frank, Finian Leeper and Ben F. Luisi,
"Structure, mechanism and catalytic duality of thiamine-dependent enzymes."
Cell. Molec. Life Sci., 2007, 64, 892-905. Abstract, Full Text.
111 Neil R. Williamson, Peter C. Fineran, Finian J. Leeper and George P. C. Salmond,
"The Regulation and Biosynthesis of Bacterial Prodiginines."
Nature Rev. Microbiol., 2006, 4, 887-899. Abstract, Full Text.
110 N. R. Williamson, H. T. Simonsen, A. K. P. Harris, F. J. Leeper and George P. C. Salmond,
"Disruption of the copper efflux pump (CopA) of Serratia marcescens ATCC 274 pleiotropically affects copper sensitivity and production of the tripyrrole secondary metabolite, prodigiosin."
J. Indust. Microbiol. Biotechnol., 2006, 33 (2), 151-158. Abstract, Full Text.
109 F. J. Leeper, D. Hawksley, S. Mann, C. Perez Melero and M. D. H. Wood,
"Studies on Thiamine Diphosphate-dependent Enzymes."
Biochem. Soc. Trans., 2005, 33 (4), 772-775. Abstract, Full Text.
108 N. R. Williamson, H. T. Simonsen, R. A. A. Ahmed, G. Goldet, H. Slater, L. Woodley, F. J. Leeper and G. P. C. Salmond,
"Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces."
Molec. Microbiology, 2005, 56 (4), 971-989. Abstract, Full Text.
107 A. K. P. Harris, N. R. Williamson, H. Slater, A. Cox, S. Abbasi, I. Foulds, H. T. Simonsen, F. J. Leeper and G. P. C. Salmond
"The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation."
Microbiology,, 2004, 150 (11), 3547-3560. Abstract, Full Text.
106 S. Mann, C. Perez Melero, D. Hawksley and F. J. Leeper
"Inhibition of thiamin diphosphate dependent enzymes by 3-deazathiamin diphosphate."
Org. Biomolec. Chem.,, 2004, 2 (12), 1732-1741. Abstract, Full Text.
105 C. E. Goodwin and F. J. Leeper
"Stereochemistry and Mechanism of the Conversion of 5-Aminolaevulinic Acid into Porphobilinogen Catalysed by Porphobilinogen Synthase."
Org. Biomolec. Chem.,, 2003, 1, 1443-1446. Abstract, Full Text, Suppl. Info.
104 R. Ahmed and F. J. Leeper
"A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase."
Org. Biomolec. Chem.,, 2003, 1, 21-23. Abstract, Full Text, Suppl. Info.
103 M. J. White and F. J. Leeper
"Kinetics of the Thiazolium Ion-Catalysed Benzoin Condensation."
J. Org. Chem.,, 2001, 66, 5124-5131. Abstract, Full Text.
102 D. Hawksley, D. A. Griffin and F. J. Leeper
"Synthesis of 3-Deazathiamine."
J. Chem. Soc., Perkin Trans. 1, 2001, 144-148. Abstract, Full Text, Suppl. Info.
101 K. Ichinose, M. Kodera, F. J. Leeper and A. R. Battersby
"Biosynthesis of porphyrins and related macrocycles. Part 51. Proof that a reductive step occurs during the biosynthesis of vitamin B12 by the micro-aerophilic organism, Propionibacterium shermanii"
J. Chem. Soc., Perkin Trans. 1, 1999, 879-887. Abstract, Full Text.
100 A. R. Battersby and F. J. Leeper
"Biosynthesis of B12 in the Aerobic Organism Pseudomonas denitrificans"
in Chemistry and Biochemistry of B12 (2nd Edn), R. Banerjee, Editor. 1999, J. Wiley & Sons, New York, p. 507-535. Abstract.
99 R. L. Knight and F. J. Leeper
"Comparison of chiral thiazolium and triazolium salts as asymmetric catalysts for the benzoin condensation"
J. Chem. Soc., Perkin Trans. 1, 1998, 1891-1893. Abstract, Full Text.
98 P. M. Petersen, C. J. Hawker, N. P. J. Stamford, F. J. Leeper and A. R. Battersby
"Biosynthesis of porphyrins and related macrocycles. Part 50. Synthesis of the N-formyl-dihydro analogue of the spiro-intermediate and its interaction with uroporphyrinogen III synthase"
J. Chem. Soc., Perkin Trans. 1, 1998, 1531-1540. Abstract, Full Text.
97 C. J. Hawker, P. M. Petersen, F. J. Leeper and A. R. Battersby
"Biosynthesis of porphyrins and related macrocycles. Part 49. Exploration of synthetic routes to analogues of the spiro-intermediate for porphyrin biosynthesis"
J. Chem. Soc., Perkin Trans. 1, 1998, 1519-1530. Abstract, Full Text.
96 C. J. Hawker, A. C. Spivey, F. J. Leeper and A. R. Battersby
"Biosynthesis of porphyrins and related macrocycles. Part 48. The rearrangement of 2H-pyrroles (pyrrolenines) related to the proposed spiro-intermediate for porphyrin biosynthesis"
J. Chem. Soc., Perkin Trans. 1, 1998, 1509-1518. Abstract, Full Text.
95 C. J. Hawker, W. M. Stark, A. C. Spivey, P. R. Raithby, F. J. Leeper and A. R. Battersby
"Biosynthesis of porphyrins and related macrocycles. Part 47. Synthesis and chemistry of 2H-pyrroles (pyrrolenines) related to the proposed spiro-intermediate for porphyrin biosynthesis"
J. Chem. Soc., Perkin Trans. 1, 1998, 1493-1508. Abstract, Full Text.
94 A. R. Battersby and F. J. Leeper
"Biosynthesis of Vitamin B12"
in Biosynthesis: Polyketides and Vitamins, Topics in Current Chemistry,Vol. 195, Springer-Verlag, Heidelberg, 1998, 143-193. Abstract Full Text.
93 G. Schenk, F. J. Leeper, R. England, P. F. Nixon and R. G. Duggleby
"The role of His113 and His114 in pyruvate decarboxylase from Zymomonas mobilis"
Eur. J. Biochem., 1997, 248, 63-71. Abstract, Full Text.
92 D. Appleton, A. B. Duguid, S.-K. Lee, Y.-J. Ha, H.-J. Ha and F. J. Leeper
"Synthesis of Analogues of 5-Aminolaevulinic Acid and Inhibition of 5-Aminolaevulinic Acid Dehydratase"
J. Chem. Soc., Perkin Trans. 1, 1998, 89-102. Abstract, Full Text.
91 J. Micklefield, M. Beckmann, R. L. Mackman, M. H. Block, F. J. Leeper and A. R. Battersby
"Haem d1: Stereoselective Synthesis of the Macrocycle to Establish its Absolute Configuration as 2R,7R"
J. Chem. Soc., Perkin Trans. 1, 1997, 2123-2138. Abstract, Full Text.
90 R. L. Mackman, J. Micklefield, M. H. Block, F. J. Leeper and A. R. Battersby
"Haem d1: Development of a new coupling procedure leading to the synthesis of isobacteriochlorins"
J. Chem. Soc., Perkin Trans. 1, 1997, 2111-2122. Abstract, Full Text.
89 C. J. Aucken, F. J. Leeper and A. R. Battersby
"Haem d1: Stereoselective synthesis of the reduced form of its parent macrocycle using the original coupling strategy"
J. Chem. Soc., Perkin Trans. 1, 1997, 2099-2109. Abstract, Full Text.
88 J. J. De Voss, F. J. Leeper and A. R. Battersby
"Synthetic studies relevant to biosynthetic research on vitamin B12. Part 12. Modification of the periphery of chlorins and isobacteriochlorins"
J. Chem. Soc., Perkin Trans. 1, 1997, 1105-1116. Abstract, Full Text.
87 A. U. Gerhard and F. J. Leeper
"Synthesis of and Asymmetric Induction by Chiral Polycyclic Thiazolium Salts"
Tetrahedron Lett., 1997, 38, 3615-3618. Abstract, Full Text.
86 R. L. Knight and F. J. Leeper
"Synthesis of and Asymmetric Induction by Chiral Bicyclic Thiazolium Salts"
Tetrahedron Lett., 1997, 38, 3611-3614. Abstract Full Text.
85 C. Gonzalez Bello, C. Abell and F. J. Leeper
"Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies"
J. Chem. Soc., Perkin Trans. 1, 1997, 1017-1024. Abstract, Full Text.
84 D. Appleton and F. J. Leeper
"Deuterium Isotope Effects on Porphobilinogen Synthesis Catalysed by 5-Aminolaevulinic Acid Dehydratase"
Bioorg. Med. Chem. Lett., 1996, 6, 1191-1194. Abstract, Full Text.
83 F. J. Leeper and M. Rock
"Interaction of Analogues of Porphobilinogen with Porphobilinogen Deaminase"
J. Chem. Soc., Perkin Trans. 1, 1996, 2643-2649. Abstract, Full Text.
82 F. J. Leeper, M. Rock and D. Appleton
"Synthesis of Analogues of Porphobilinogen"
J. Chem. Soc., Perkin Trans. 1, 1996, 2633-2642. Abstract Full Text.
81 A. C. Spivey, A. Capretta, C. S. Frampton, F. J. Leeper and A. R. Battersby
"Biosynthesis of Porphyrins and Related Macrocycles, Part 45. Determination of the Absolute Configuration of the Spirolactam which Inhibits Cosynthetase"
J. Chem. Soc., Perkin Trans. 1, 1996, 2091-2102. Abstract Full Text.
80 M. A. Cassidy, N. Crockett, F. J. Leeper and A. R. Battersby
"Biosynthesis of Porphyrins and Related Macrocycles, Part 44. Synthetic and Stereochemical Studies on the Proposed Spiro Intermediate for Biosynthesis of the Natural Porphyrins"
J. Chem. Soc., Perkin Trans. 1, 1996, 2079-2090. Abstract Full Text.
79 D. Appleton and F. J. Leeper
"Mechanism-based Inhibition of 5-Aminolaevulinic Acid Dehydratase from Bacillus subtilis by the 3-Thia Analogue of the Substrate"
Chem. Commun., 1996, 303-304. Abstract Full Text.
78 C. Lawrence, I. M. Bell, C. Abell and F. J. Leeper
"Approaches to Antibody-catalysed Cationic Cyclisations: Chemical Studies of Leaving Groups and Cyclisation Modes"
Isr. J. Chem., 1996, 36, 161-169. Abstract.
77 A. C. Spivey, A. Capretta, C. S. Frampton, F. J. Leeper and A. R. Battersby
"Stereochemical Studies on the Proposed Spiro Intermediate for the Biosynthesis of the Natural Porphyrins: Determination by a Novel X-Ray Method of the Absolute Configuration of the Spirolactam which Inhibits Cosynthetase"
J. Chem. Soc., Chem. Commun., 1995, 1789-1790. Abstract, Full Text.
76 F. Kiuchi, F. J. Leeper and A. R. Battersby
"Biosynthesis of Porphyrins and Related Macrocycles, Part 43. Isolation and Characterisation of Intermediates of Coenzyme B12 Biosynthesis, a Cobyrinic Acid Triamide, the a,c-diamide and their Co-(5'-Deoxy-5'-adenosyl) derivatives, from Propionibacterium shermanii"
Chemistry & Biology, 1995, 2, 527-532. Abstract, Full Text.
75 F. J. Leeper and S. Howard
"Stereocontrolled Syntheses of Polyhydroxy Indolizidines, Including 8a-Epi, 6,8a-Diepi and 1,6-Diepi-castanospermine, Starting from Malic Acid"
Tetrahedron Lett., 1995, 36, 2335-2338. Abstract, Full Text.
74 F. J. Leeper, D. H. C. Smith, M. J. Doyle and P. R. Raithby
"Bridged Thiazolium Salts as Models for Thiamin: NMR, Crystallographic and Molecular Mechanics Studies"
J. Chem. Soc., Perkin Trans. 2, 1995, 777-784. Abstract, Full Text.
73 F. J. Leeper and D. H. C. Smith
"Bridged Thiazolium Salts as Models for Thiamin: Synthesis and Reactions"
J. Chem. Soc., Perkin Trans. 1, 1995, 861-873. Abstract, Full Text.
72 Y. Li, A. I. D. Alanine, S. Balachandran, R. A. Vishwakarma, F. J. Leeper and A. R. Battersby
"Biosynthesis of Vitamin B12: Mechanistic Studies on the Transfer of a Methyl Group from C-11 to C-12 and Incorporation of 18O"
J. Chem. Soc., Chem. Commun., 1994, 2507-2508. Abstract, Full Text.
71 A. I. D. Alanine, Y. Li, N. P. J. Stamford, F. J. Leeper, F. Blanche, L. Debussche and A. R. Battersby
"Biosynthesis of Vitamin B12: Studies of the Oxidative and Lactone-forming Steps by 18O-Labelling"
J. Chem. Soc., Chem. Commun., 1994, 1649-1650. Abstract, Full Text.
70 F. Blanche, B. Cameron, J. Crouzet, L. Debussche, D. Thibaut, M. Vuilhorgne, F. J. Leeper and A. R. Battersby
"Vitamin B12: How the Problem of its Biosynthesis was Solved"
Angew. Chem., Int. Ed. Engl., 1995, 34, 383-411. Abstract, Full Text.
69 I. M. Bell, C. Abell and F. J. Leeper
"Design and Synthesis of Transition State Analogues for a Cationic Cyclisation"
J. Chem. Soc., Perkin Trans.1, 1994, 1997-2006. Abstract, Full Text.
68 S. Balachandran, R. A. Vishwakarma, S. M. Monaghan, A. Prelle, N. P. J. Stamford, F. J. Leeper and A. R. Battersby
"Biosynthesis of Porphyrins and Related Macrocycles, Part 42. Pulse Labelling Experiments Concerning the Timing of Cobalt Insertion During Vitamin B12 Biosynthesis"
J. Chem. Soc., Perkin Trans. 1, 1994, 487-491. Abstract, Full Text.
67 K. E. Holt, F. J. Leeper and S. Handa
"Synthesis of beta-1-Homonojirimycin and beta-1-Homomannojirimycin using the Enzyme Aldolase"
J. Chem. Soc., Perkin Trans.1, 1994, 231-234. Abstract, Full Text.
66 A. I. D. Alanine, K. Ichinose, D. Thibaut, L. Debussche, N. P. J. Stamford, F. J. Leeper, F. Blanche and A. R. Battersby
"Biosynthesis of Vitamin B12: Use of Specific 13C-Labelling for Structural Studies on Factor IV"
J. Chem. Soc., Chem. Commun., 1994, 193-196. Abstract, Full Text.
65 R. A. Vishwakarma, S. Balachandran, A. I. D. Alanine, N. P. J. Stamford, F. Kiuchi, F. J. Leeper and A. R. Battersby
"Biosynthesis of Porphyrins and Related Macrocycles. Part 41. Fate of Oxygen Atoms as Precorrin-2 Carrying Eight Labelled Carboxyl Groups (13C18O2H) is Enzymatically Converted into Cobyrinic Acid"
J. Chem. Soc., Perkin Trans. 1, 1993, 2893-2899. Abstract, Full Text.
64 W. M. Stark, C. J. Hawker, G. J. Hart, A. Philippides, P. M. Petersen, J. D. Lewis, F. J. Leeper and A. R. Battersby
"Biosynthesis of Porphyrins and Related Macrocycles, Part 40. Synthesis of a Spiro-Lactam Related to the Proposed Spiro-Intermediate for Porphyrin Biosynthesis: Inhibition of Cosynthetase"
J. Chem. Soc., Perkin Trans. 1, 1993, 2875-2892. Abstract, Full Text.
63 F. J. Leeper, S. E. Shaw and P. Satish
"The Biosynthesis of Cyclizidine: Incorporation of Singly and Doubly Labelled Precursors"
Can. J. Chem., 1994, 72, 131-141. Abstract, Full Text.
62 F. J. Leeper
"Evidence for a Spirocyclic Intermediate in the Formation of Urogen III by Cosynthetase"
in The Biosynthesis of the Tetrapyrrole Pigments, 1994, J. Wiley & Sons, Chichester, p. 111-123. Abstract, Full Text.
61 K. Ichinose, F. J. Leeper and A. R. Battersby
"Preparation of [4R-3H]NADH, [4R-3H]NADPH and the Corresponding 4S-Isomers All with Substantial Specific Activities"
J. Chem. Soc., Perkin Trans. 1,1993, 1213-1216. Abstract, Full Text.
60 K. Ichinose, M. Kodera, F. J. Leeper and A. R. Battersby
"Proof that the Biosynthesis of Vitamin B12 Involves a Reduction Step in an Anaerobic as well as an Aerobic Organism"
J. Chem. Soc., Chem. Commun., 1993, 515-517. Abstract, Full Text.
59 J. Micklefield, R. L. Mackman, C. J. Aucken, M. Beckmann, M. H. Block, F. J. Leeper and A. R. Battersby
"A Novel Stereoselective Synthesis of the Macrocycle of Heme d1 that Establishes its Absolute Configuration as 2R,7R"
J. Chem. Soc., Chem. Commun., 1993, 275-277. Abstract, Full Text.
58 A. R. Battersby, M. H. Block, F. J. Leeper and S. C. Zimmerman
"Synthetic Studies Relevant to Biosynthetic Research on Vitamin B12, Part 11. Modification of the East and West Building Blocks and Study of Different Assembly Methods for Synthesis of Isobacteriochlorins"
J. Chem. Soc., Perkin Trans. 1, 1992, 2189-2195. Abstract, Full Text.
57 A. R. Battersby, M. H. Block, C. J. R. Fookes, P. J. Harrison, G. B. Henderson and F. J. Leeper
"Synthetic Studies Relevant to Biosynthetic Research on Vitamin B12, Part 10. Construction of the East and West Building Blocks for Synthesis of Isobacteriochlorins"
J. Chem. Soc., Perkin Trans. 1, 1992, 2175-2188. Abstract, Full Text.
56 D. Thibaut, F. Kiuchi, L. Debussche, F. Blanche, M. Kodera, F. J. Leeper and A. R. Battersby
"Biosynthesis of Vitamin B12: Structural Studies on Precorrin-8x, an Octamethylated Intermediate and the Structure of its Stable Tautomer"
J. Chem. Soc., Chem. Commun., 1992, 982-985. Abstract, Full Text.
55 M. Kodera, F. J. Leeper and A. R. Battersby
"Biosynthesis of Vitamin B12: The Fate of H-8 as Precorrin-2 is Enzymically Converted into Cobyrinic Acid"
J. Chem. Soc., Chem. Commun., 1992, 835-837. Abstract, Full Text.
54 F. J. Leeper and M. Rock
"Modified Substrates for Tetrapyrrole Biosynthesis: Analogues of Porphobilinogen Showing Unusual Inhibition of Porphobilinogen Deaminase"
J. Chem. Soc., Chem. Commun., 1992, 242-244. Abstract, Full Text.
53 F. Kiuchi, D. Thibaut, L. Debussche, F. J. Leeper, F. Blanche and A. R. Battersby
"Biosynthesis of Vitamin B12: Stereochemistry of Transfer of a Hydride Equivalent from NADPH by Precorrin-6x Reductase"
J. Chem. Soc., Chem. Commun., 1992, 306-308. Abstract, Full Text.
52 D. Thibaut, F. Kiuchi, L. Debussche, F. J. Leeper, F. Blanche and A. R. Battersby
"Biosynthesis of Vitamin B12: Structure of the Ester of a New Biosynthetic Intermediate, Precorrin-6y"
J. Chem. Soc., Chem. Commun., 1992, 139-141. Abstract, Full Text.
51 F. Blanche, M. Kodera, M. Couder, F. J. Leeper, D. Thibaut and A. R. Battersby
"Biosynthesis of Vitamin B12: Use of a Single 13C Label in the Macrocycle to Confirm C-11 Methylation in Precorrin-6x"
J. Chem. Soc., Chem. Commun., 1992, 138-139. Abstract, Full Text.
50 G. W. Weaver, F. J. Leeper, A. R. Battersby, F. Blanche, D. Thibaut and L. Debussche
"Biosynthesis of Vitamin B12: the Site of Reduction of Precorrin-6x"
J. Chem. Soc., Chem. Commun., 1991, 976-979. Abstract, Full Text.
49 M. A. Cassidy, N. Crockett, F. J. Leeper and A. R. Battersby
"Synthetic Studies on the Proposed Spiro Intermediate for Biosynthesis of the Natural Porphyrins: The Stereochemical Probe"
J. Chem. Soc., Chem. Commun., 1991, 384-386. Abstract, Full Text.
48 F. J. Leeper
"Intermediate Steps in the Biosynthesis of Chlorophylls"
in Chlorophylls, H. Scheer, Editor. 1991, CRC Press, Boca Raton, p. 407-431. Abstract.
47 F. J. Leeper and M. Rock
"Synthesis of a Fluorinated Analogue of 5-Aminolaevulinic Acid, a Potential Inhibitor of Porphyrin Biosynthesis"
J. Fluor. Chem., 1991, 51, 381-396. Abstract, Full Text.
46 D. Thibaut, L. Debussche, F. Blanche, F. J. Leeper and A. R. Battersby
"Biosynthesis of Vitamin B12: The Structure of Precorrin-6x Octamethyl Ester"
Proc. Natl. Acad. Sci. USA, 1990, 87, 8800-8804. Abstract, Full Text.
45 A. R. Battersby and F. J. Leeper
"Biosynthesis of the Pigments of Life: Mechanistic Studies on the conversion of Porphobilinogen into Uroporphyrinogen III"
Chem. Rev., 1990, 90, 1261-1274. Abstract, Full Text.
44 G. W. Weaver, F. Blanche, D. Thibaut, L. Debussche, F. J. Leeper and A. R. Battersby
"Biosynthesis of Vitamin B12: Incorporation of 11S-[11-2H]- and 11R-[11-2H]-Porphobilinogen into Sirohydrochlorin and 2,7,20-Trimethylisobacteriochlorin"
J. Chem. Soc., Chem. Commun., 1990, 1125-27. Abstract, Full Text.
43 F. J. Leeper and D. H. C. Smith
"The Effect of Strain on the Catalytic Reactions of Bridged Thiazolium Salts as Models of Thiamin"
J. Chem. Soc., Chem. Commun., 1990, 961-963. Abstract, Full Text.
42 G. J. Hart, A. D. Miller, U. Beifuss, F. J. Leeper and A. R. Battersby
"Biosynthesis of Porphyrins and Related Macrocycles, Part 35. Discovery of a Novel Dipyrrolic Cofactor Essential for the Catalytic Action of Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)"
J. Chem. Soc., Perkin Trans. 1, 1990, 1979-1993. Abstract, Full Text.
41 F. J. Leeper and P. Padmanabhan
"Stereospecific Nucleophilic Ring-Opening of a Deuteriated Cyclopropylcarbinol"
Tetrahedron Lett., 1989, 30, 5017-5020. Abstract, Full Text.
40 F. J. Leeper and A. R. Battersby
"Chirally Tritiated and Deuteriated Compounds in Studies of Biosynthesis"
in Synthesis and Applications of Isotopically Labelled Compounds (Proceedings of the Third International Symposium). 1989, Elsevier, p. 41-46. Abstract.
39 B. Muller, A. N. Collins, M. K. Ellis, W. G. Whittingham, F. J. Leeper and A. R. Battersby
"Syntheses Relevant to Vitamin B12 Biosynthesis: The Glutamate Route to (-)-Ring-B Imide and Synthesis of the 2,7,12,20-Tetramethylisobacteriochlorin"
J. Chem. Soc., Chem. Commun., 1989, 1119-1122. Abstract, Full Text.
38 W. G. Whittingham, M. K. Ellis, P. Guerry, G. B. Henderson, B. Muller, D. A. Taylor, F. J. Leeper and A. R. Battersby
"Syntheses Relevant to Vitamin B12 Biosynthesis: The Malate Route to (-)-Ring-B Imide and Synthesis of the 2,7,20-Trimethylisobacteriochlorin"
J. Chem. Soc., Chem. Commun., 1989, 1116-1119. Abstract, Full Text.
37 A. D. Miller, F. J. Leeper and A. R. Battersby
"Biosynthesis of Porphyrins and Related Macrocycles, Part 34. Synthesis and Properties of S-Pyrrolylmethylcysteinyl and e-N-Pyrrolylmethyl-lysyl Peptides"
J. Chem. Soc., Perkin Trans. 1, 1989, 1943-1956. Abstract, Full Text.
36 F. J. Leeper
"The Biosynthesis of Porphyrins, Chlorophylls, and Vitamin B12"
Natural Products Reports, 1989, 6, 171-203. Abstract, Full Text.
35 R. D. Brunt, F. J. Leeper, I. Grgurina and A. R. Battersby
"Biosynthesis of Vitamin B12: Synthesis of (±)-[5-13C]Faktor-1 Ester: Determination of the Oxidation State of Precorrin-1"
J. Chem. Soc., Chem. Commun., 1989, 428-431. Abstract, Full Text.
34 P. R. Alefounder, G. J. Hart, A. D. Miller, U. Beifuss, C. Abell, F. J. Leeper and A. R. Battersby
"Biosynthesis of the Pigments of Life: Structure and Mode of Action of a Novel Enzymatic Cofactor"
Bioorg. Chem., 1989, 17, 121-129. Abstract, Full Text.
33 D. M. Arnott, P. J. Harrison, G. B. Henderson, Z.-C. Sheng, F. J. Leeper and A. R. Battersby
"Synthetic Studies Relevant to Research on Vitamin B12, Part 9. Synthesis of 20-Methyl and 20-Cyano Isobacteriochlorins"
J. Chem. Soc., Perkin Trans. 1, 1989, 265-278. Abstract, Full Text.
32 F. Blanche, S. Handa, D. Thibaut, C. L. Gibson, F. J. Leeper and A. R. Battersby
"Biosynthesis of Vitamin B12: When is the 12b-Methyl Group of the Vitamin Generated by Acetate Decarboxylation?"
J. Chem. Soc., Chem. Commun., 1988, 1117-1119. Abstract, Full Text.
31 W. M. Stark, M. G. Baker, F. J. Leeper, P. R. Raithby and A. R. Battersby
"Biosynthesis of Porphyrins and Related Macrocycles, Part 30. Synthesis of the Macrocycle of the Spiro System Proposed as an Intermediate Generated by Cosynthetase"
J. Chem. Soc., Perkin Trans. 1,1988, 1187-1201. Abstract, Full Text.
30 A. K. Demetriadou, E. D. Laue, F. J. Leeper and J. Staunton
"Isolation and Structure Elucidation of Polivione, a Polyketide Co-metabolite of Citromycetin in Penicillium frequentans"
J. Chem. Soc., Perkin Trans. 1, 1988, 763-768. Abstract, Full Text.
29 F. J. Leeper and D. H. C. Smith
"Synthesis and Structure of Bridged Thiazolium Salts"
Tetrahedron Lett., 1988, 29, 1325-1328. Abstract, Full Text.
28 G. J. Hart, A. D. Miller, F. J. Leeper and A. R. Battersby
"Biosynthesis of the Natural Porphyrins: Proof that Hydroxymethylbilane Synthase (Porphobilinogen Deaminase) uses a Novel Binding Group in its Catalytic Action"
J. Chem. Soc., Chem. Commun., 1987, 1762-1764. Abstract, Full Text.
27 F. J. Leeper, P. Padmanabhan, G. W. Kirby and G. N. Sheldrake
"Biosynthesis of the Indolizidine Alkaloid, Cyclizidine"
J. Chem. Soc., Chem. Commun., 1987, 505-506. Abstract, Full Text.
26 F. J. Leeper
"The Biosynthesis of Porphyrins, Chlorophylls, and Vitamin B12"
Natural Products Reports, 1987, 4, 441-469. Abstract, Full Text.
25 A. R. Battersby, M. G. Baker, H. A. Broadbent, C. J. R. Fookes and F. J. Leeper
"Biosynthesis of Porphyrins and Related Macrocycles, Part 29. Synthesis and Chemistry of 2,2-Disubstituted 2H-Pyrroles (Pyrrolenines)"
J. Chem. Soc., Perkin Trans. 1, 1987, 2027-2048. Abstract, Full Text.
24 H. C. Uzar, A. R. Battersby, T. A. Carpenter and F. J. Leeper
"Biosynthesis of Porphyrins and Related Macrocycles, Part 28. Development of a Pulse Labelling Method to Determine the C-Methylation Sequence for Vitamin B12"
J. Chem. Soc., Perkin Trans. 1, 1987, 1689-1696. Abstract, Full Text.
23 A. R. Battersby, K. S. Cardwell and F. J. Leeper
"Stereochemical Studies on Porphyrin a: Assignment of the Absolute Configuration of a Model Porphyrin by Degradation"
J. Chem. Soc., Perkin Trans. 1, 1986, 1565-1580. Abstract, Full Text.
22 F. J. Leeper
"The Biosynthesis of Porphyrins, Chlorophylls, and Vitamin B12"
Natural Products Reports, 1985, 2, 561-580. Abstract, Full Text.
21 W. M. Stark, M. G. Baker, P. R. Raithby, F. J. Leeper and A. R. Battersby
"The Spiro-Intermediate Proposed for Biosynthesis of the Natural Porphyrins: Synthesis and Properties of its Macrocycle"
J. Chem. Soc., Chem. Commun., 1985, 1294-1296. Abstract, Full Text.
20 M. H. Block, S. C. Zimmerman, G. B. Henderson, S. P. D. Turner, S. W. Westwood, F. J. Leeper and A. R. Battersby
"Syntheses Relevant to Vitamin B12 Biosynthesis: Synthesis of Sirohydrochlorin and of its Octamethyl Ester"
J. Chem. Soc., Chem. Commun., 1985, 1061-1063. Abstract, Full Text.
19 A. K. Demetriadou, E. D. Laue, F. J. Leeper and J. Staunton
"The Structure of Polivione, a Polyketide Co-metabolite of Citromycetin in Penicillium frequentans"
J. Chem. Soc., Chem. Commun., 1985, 762-764. Abstract, Full Text.
18 F. J. Leeper
"The Biosynthesis of Porphyrins, Chlorophylls, and Vitamin B12"
Natural Products Reports, 1985, 2, 19-47. Abstract, Full Text.
17 D. M. Doddrell, E. D. Laue, F. J. Leeper, J. Staunton, A. Davies, A. B. Davies and G. A. F. Ritchie
"Biosynthesis of the Polyether Antibiotic ICI 139603 in Streptomyces longisporoflavus: Investigation of Deuterium Retention after Incorporation of CD313CO2H, 13CD3CO2H, and CH3CD213CO2H using 2H NMR and edited 13C NMR Spectra"
J. Chem. Soc., Chem. Commun., 1984, 1302-1304. Abstract, Full Text.
16 J. M. Bulsing, E. D. Laue, F. J. Leeper, J. Staunton, D. H. Davies, G. A. F. Ritchie, A. Davies, A. B. Davies and R. P. Mabelis
"Biosynthesis of the Polyketide Antibiotic ICI 139603 in Streptomyces longisporoflavus: Assignment of the 13C NMR by Two-Dimensional Methods and Determination of the Origin of the Carbon Atoms"
J. Chem. Soc., Chem. Commun., 1984, 1301-1302. Abstract, Full Text.
15 F. J. Leeper and J. Staunton
"The Biosynthesis of Rubrofusarin, a Polyketide Naphthopyrone from Fusarium culmorum: 13C NMR Assignments and Incorporation of 13C and 2H-Labelled Acetates"
J. Chem. Soc., Perkin Trans. 1, 1984, 2919-2925. Abstract, Full Text.
14 G. J. Hart, F. J. Leeper and A. R. Battersby
"Modification of hydroxymethylbilane synthase (porphobilinogen deaminase) by pyridoxal 5-phosphate"
Biochem. J., 1984, 222, 93-102. Abstract, Full Text.
13 F. J. Leeper and J. Staunton
"Biomimetic Syntheses of Polyketide Aromatics from Reaction of an Orsellinate Anion with Pyrones and a Pyrylium Salt"
J. Chem. Soc., Perkin Trans. 1, 1984, 1053-1059. Abstract, Full Text.
12 T. A. Carpenter, G. E. Evans, F. J. Leeper, J. Staunton and M. R. Wilkinson
"Reactions of the Carbanion from an Orsellinate Derivative with Electrophiles"
J. Chem. Soc., Perkin Trans. 1, 1984, 1043-1051. Abstract, Full Text.
11 D. A. Griffin, F. J. Leeper and J. Staunton
"Biomimetic Syntheses of Polyketide Aromatics from Pyrylium Salts"
J. Chem. Soc., Perkin Trans. 1, 1984, 1035-1042. Abstract, Full Text.
10 F. J. Leeper and P. N. Lowe
"The Stereochemistry and Conformation of the Diastereomers of Tetrahydrothiamin"
Heterocycles, 1983, 20, 65-68. Abstract, Full Text.
09 P. N. Lowe, F. J. Leeper and R. N. Perham
"Stereoisomers of Tetrahydrothiamin Pyrophosphate, Potent Inhibitors of the Pyruvate Dehydrogenase Multienzyme Complex from Escherichia coli"
Biochemistry, 1983, 22, 150-157. Abstract, Full Text.
08 C. Abell, M. J. Garson, F. J. Leeper and J. Staunton
"Biosynthesis of Fungal Metabolites, Alternariol, Mellein, Rubrofusarin and 6-Methylsalicylic Acid from CD3CO2H"
J. Chem. Soc., Chem. Commun., 1982, 1011-1013. Abstract, Full Text.
07 F. J. Leeper and J. Staunton
"Rubrofusarin Biosynthesis in Fusarium culmorum: Incorporation of 13CH313CO2H and CD313CO2H into the Polyketide Naphthalene Nucleus"
J. Chem. Soc., Chem. Commun., 1982, 911-912. Abstract, Full Text.
06 F. J. Leeper, G. Grue-Sorensen and I. D. Spenser
"Biosynthesis of the Quinolizidine Alkaloids. Incorporation of delta-1-Piperideine into Matrine"
Canad. J. Chem., 1981, 59, 106-115. Abstract, Full Text.
05 T. A. Carpenter, P. J. Jenner, F. J. Leeper and J. Staunton
"A Novel Kinetic Deprotonation at a Vinylic Carbon in a Pyrone Ring"
J. Chem. Soc., Chem. Commun., 1980, 1227. Abstract, Full Text.
04 F. J. Leeper and J. Staunton
"Triacetic Lactone and 2,6-Dimethyl-g-pyrone as Polyketide Synthons: Syntheses of Torachrysone and Eleutherinol Derivatives"
J. Chem. Soc., Chem. Commun., 1979, 206-207. Abstract, Full Text.
03 G. E. Evans, F. J. Leeper, J. A. Murphy and J. Staunton
"Triacetic Lactone as a Polyketide Synthon: Syntheses of Toralactone and Polyketide-type Anthracene Derivatives"
J. Chem. Soc., Chem. Commun., 1979, 205-206. Abstract, Full Text.
02 F. J. Leeper and J. Staunton
"Biomimetic Syntheses of Heptaketide Metabolites: Alternariol and a Derivative of Rubrofusarin"
J. Chem. Soc., Chem. Commun., 1978, 406-407. Abstract, Full Text.
01G. E. Evans, M. J. Garson, D. A. Griffin, F. J. Leeper and J. Staunton
"Biomimetic Syntheses of Phenols from Polyketones"
in Further Perspectives in Organic Chemistry, 1978, Elsevier, Amsterdam, p. 138. Abstract, Full Text.
Books Edited
3 "Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids" (Topics in Current Chemistry, Vol. 209)
Ed. F. J. Leeper & J. C. Vederas, Springer-Verlag, Berlin, 2000.
2 "Biosynthesis: Polyketides and Vitamins" (Topics in Current Chemistry, Vol. 195)
Ed. F. J. Leeper & J. C. Vederas, Springer-Verlag, Berlin, 1998.
1 "Dictionary of Natural Products", Vols 1 to 7
Ed. J. Buckingham, D. C. Ayres, B. W. Bycroft, P. M. Collins, F. D. Gunstone, J. B. Harborne, E. Haslam, R. A. Hill, D. R. Kelly, F. J. Leeper, R. D. H. Murray & I. W. Southon, Chapman & Hall, New York, 1994.
Book Reviews
2 "Iminosugars as Glycosidase Inhibitors"
Ed. A. E. Stutz, Wiley-VCH, reviewed in Nat. Prod. Rep., 1999.
1 A. Jacobs "Understanding Organic Reaction Mechanisms"
and M. Edenborough "Organic Reaction Mechanisms"
reviewed in Chem@Cam, 1999, 5, 16.
    

Department of Chemistry
University of Cambridge