Abstract

90
R. L. Mackman, J. Micklefield, M. H. Block, F. J. Leeper and A. R. Battersby
"Haem d₁: Development of a new coupling procedure leading to the synthesis of isobacteriochlorins"
J. Chem. Soc., Perkin Trans. 1, 1997, 2111-2122. Full Text

A new approach has been developed for construction of the western and eastern lactams needed for synthesis of isobacteriochlorins. It involves acylation of pyrroles with lactonic acids to form ketones. These are then efficiently converted into the desired lactams by a short sequence of reactions. All the steps are high yielding and simple to carry out.

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