Leeper Group

   

Current Members

Finian Leeper Finian Leeper has been on the academic staff at Cambridge since 1982 (see curriculum vitae for more details). Fellow, Graduate Tutor (1998-2011) and Director of Studies in Chemistry at Emmanuel College. On the Department's Postgraduate Student Affairs Committee and Equipment Committee. Previously on the Editorial Board of Natural Product Reports, a University Procter and Chairman of Examiners for Natural Science Tripos Parts IB, II & III.
Other than chemistry (of course), interests include computers, sport and family history. Treasurer (and webmaster) of the Department Cricket Team.
E-mail address: FJL1@cam.ac.uk.

 

Photo of Yelena Yelena Wainman. Ph.D. student Jul 2011-present. Funded by C.R.U.K. Medicinal Chemistry Programme, co-supervisor Prof Kevin Brindle
Project: New methods for Glycan Detection

Yelena graduated from University College London with a First Class Honours MSci Degree in Natural Sciences in 2010, after receiving the Natural Sciences Sessional Prize (2007-2008) and the Dean's List Award (2009-2010). Yelena spent her third year as an exchange student at the Ecole Normale Superieure in Lyon. In her final year research project, she worked on the design and synthesis of cathepsin inhibitors for dendritic cells.

Outside the lab, Yelena is a keen pianist and is involved in various chamber music groups around Cambridge. She also enjoys travelling, skiing and hiking.

 

Photo of Beatrice Beatrice Longo. ERASMUS Placement Student from University of Perugia
Project: Synthesis and Use in Imaging of Cyclopropenyl Carbamate Sugars

 

Photo of Flaviu Flaviu Bulat. Ph.D. student Oct 2014-present. Funded by Cambridge-Manchester Cancer Imaging Centre, co-supervisor Prof Kevin Brindle
Project: Imaging Cell-Death and Glycans in Cancer

 

Photo of Emma Emma Durham. Ph.D. student Oct 2014-present. Funded by E.P.S.R.C.
Project: New NHC catalysts Incorporating Hydrogen-bonding Motifs

 

Photo of Isabelle Isabelle Schmartz. ERASMUS student Oct 2014-Mar 2015. From Philipps University, Marburg, Germany
Project: Synthesis of Thiamine Monophosphate Analogues

 

Photo of Tatiana Tatiana Garcia-Vilaplana. Part III project student Oct 2014-Mar 2015.
Project: Synthesis and Reactions of Strained trans-Cyclooctenes

 

 

Former Members

 

Group Dinner Oct 2014
Group Dinner Oct 2014

Will Crone was a Ph.D. student Jul 2011-Aug 2014. Funded by B.B.S.R.C., co-supervised by Dr Andy Truman.
Project: Biosynthesis of Bottromycin.
Worked at Bactevo Ltd in Cambridge 2014- [
Photo].

Ines Truebenbach was a Diplom in Pharmacy student from Freiburg University doing her project in our lab Oct 2013-Mar 2014.
Project: Synthesis of cyclopropenyl amide sugars.

Laia Josa Cullere. M.Phil. student, Oct 2012-Sep 2013
Project: Synthesis of water soluble (E,E)-cyclooctadiene derivatives.
D.Phil. student at Oxford 2013-. [
Photo]

Seongmin Eun. M.Phil. student, Oct 2012-Sep 2013
Project: Synthesis of TPP analogues.
[
Photo]

Most of Group
Most of the group 2012-13

Shaun Stairs. Part III project student, Oct 2008-March 2009, then Ph.D. student Oct 2009-Mar 2013
Project: Synthesis of cycloalkynes and other new methods for cancer imaging.
Post-doc at U.C.L. in Matthew Powner's group 2013-. [
Photo]

Amjid Iqbal. Ph.D. student, Oct 2008-Sep 2012.
Project: Synthesis and Evaluation of Thiamin Diphosphate Analogues.
[
Photo]

Johanna Penner. Master's project student Aug 2011-Dec 2011.
Project: New synthetic routes to thiamine analogues

Yi Luo. Part III project student, Oct 2011-March 2012.
Project: Synthesis of a ligand for affinity chromatography of TPP-dependent enzymes

Henning Stöckmann. Ph.D. student, Jul 2008-Sep 2011. Funded by CRUK Medicinal Chemistry Programme, co-supervisor Prof Kevin Brindle
Project: New Methods for Imaging Cancer.
Post-doc in Pauline Rudd's group at The National Institute for Bioprocessing Research & Training, Dublin, 2012-. [
Photo]

Dave Allman. Part III project student, Oct 2010-March 2011.
Project: Synthesis of polyketide intermediates with Dr Frank Hahn

Mark Piper. Part III project student, Oct 2010-March 2011.
Project: Synthesis and reactions of cyclooctynes.

Henry Day. Part III project student, Oct 2010-March 2011.
Project: Synthesis and reactions of (E,E)-1,4-cyclooctadiene.
PhD student at University of East Anglia 2011-. [
Photo]

Hiral Bhalara. Ph.D. student, Oct 2007-Dec 2010.
Project: Studies on the Biosynthesis of Prodigiosin.
Previously at NIPER, India. [
Photo]

Roeya Rehman. MPhil student, Oct 2009-Nov 2010
Project: Studies on pyruvate dehydrogenase E1 subunit.

Liu Chen. Ph.D. student, joint with Chris Abell, Oct 2006-Mar 2011.
Project: Studies on TPP-responsive Riboswitches.
Previously at Cambridge. [
Photo]

James Kelly. Ph.D. student, Oct 2006-Sep 2010.
Project: Synthesis and study of conformationally restrained analogues of porphobilinogen.
Previously at Harvard. Now a post-doc in Madrid. [
Photo]

Covadonga Blasco-Per. Part III project student, Oct 2009-March 2010.
Project: Synthesis of dethia-Coenzyme A derivatives.

Nick Milton. Part III project student, Oct 2009-March 2010.
Project: .

Ben McLeod. Part III project student, Oct 2009-March 2010.
Project: Synthesis and evaluation of cyclic imine carboxylates for Ugi coupling.

Suresh Chawrai. Ph.D. student, Oct 2006-Dec 2009.
Project: Studies on the Biosynthesis of Prodigiosin.
Previously at NIPER, India. Now at Vyome Biosciences Pvt Ltd based in New Delhi. [
Photo]

Kwasi Agyei-Owusu was a Ph.D. student, Oct 2005-Jun 2009.
Project: Synthesis and Evaluation of Thiamin Diphosphate Analogues.
Previously at University College, London. Started as a teacher in Birmingham in 2009. [
Photo]

Ariel Li was a Part III project student, Oct 2008-March 2009.
Project: Synthesis of dethia-Coenzyme A derivatives.

Daniel Diggins was a Summer Student Jul-Aug 2008 and then a Part III project student, Oct 2008-March 2009.
Project: Synthesis and Evaluation of Analogues of Prodigiosin Precursors.

Karl Erixon was a Ph.D. student, Oct 2005-Sep 2008, funded by ChemBioCam (a European Research Training Programme).
Project: Synthesis and Evaluation of Thiamin Diphosphate Analogues using click chemistry.
Previously at Chalmers University, Sweden. Worked for AstraZeneca in Sweden. Now a patent agent. [
Photo]

Rosalind Drywood (Posy) was a Part III project student, Oct 2007-March 2008.
Project: Synthesis of a para-benzene analogue of thiamin.

Rebecca Thomas was a Part III project student, Oct 2007-March 2008.
Project: Biomimetic Synthesis of Porphobilinogen. [
Photo]

Dean Hanafy was a Part III project student, Oct 2007-March 2008.
Project: Synthesis of Stibene Derivatives for PET Imaging of Alzheimer's Disease.

Martin Wood was a Ph.D. student, Oct 2003-Sept 2007 (oral 17/12/07).
Project: Synthesis and Evaluation of Selective Thiamin Diphosphate Antagonists. [
Photo]

Mary Manu-Marfo was a Ph.D. student, Oct 2003-Aug 2007. Co-supervised by Dr Franklin Aigbirhio, Wolfson Brain Imaging Centre.
Ph.D. project: Development of new methods for the synthesis of PET tracers. [Photo]

Nick Folkard was Part III project student, Oct 2006-March 2007.
Project: Biomimetic Synthesis of Porphobilinogen.

Jonathan Ng was a Part III project student, Oct 2006-March 2007.
Project: Improved Synthesis of Deazathiamine.

Kate Langley was a Part III project student, Oct 2005-March 2006.
Project: Synthesis of Chiral Triazolium Catalysts.

Tim Hupfield was a Part III project student, Oct 2005-March 2006.
Project: Synthesis of fluorinated stilbenes for PET imaging of Alzheimer's disease.

Filip Wyszynski was a Part III project student, Oct 2005-March 2006.
Project: Synthesis of a benzene analogue of thiamine. [
Photo]

Chester Dabalos was an M.Phil. student, Oct 2004-Sept 2005.
Project: Synthesis and Evaluation of Thiamin Diphosphate Analogues using click chemistry.

D. J. "Stan" Fowler was a Post-doc, Feb 2005-Jun 2005.
Project: Synthesis and Evaluation of Thiamin Diphosphate Analogues using click chemistry.
Previously a PhD student with David O'Hagan (Durham) and post-doc with Joe Spencer (Cambridge). Now working for EPSRC in Swindon.
E-mail address: stanfowler@yahoo.com

Richard Horrocks was a Part III project student, Oct 2004-March 2005.
Project: Synthesis of Intermediates in Prodigiosin Biosynthesis.

Tom Carr was a Part III project student, Oct 2004-March 2005.
Project: Synthesis of and catalysis by Chiral Triazolium Salts.

Philip Nash was a Part III project student, Oct 2004-March 2005.
Project: Synthesis of and catalysis by Chiral Triazolium Salts.

Whole Group
The whole group November 2002

Henrik T. Simonsen was a Post-doc, May 2002-August 2004.
Project: Biosynthesis of Prodigiosins",
Previously Ph.D. student at the Royal Danish School of Pharmacy, Copenhagen. Now Associate Professor at the Department of Plant Biology and Biotechnology, University of Copenhagen.
E-mail address: hts@life.ku.dk,
website [Photo]

Paul Goodwin was a Ph.D. student jointly with Prof. L. D. Hall, Herchel Smith Laboratory for Medicinal Chemistry, Oct 2000-2004. Examined 24th November 2004.
Ph.D. project: Synthesis and use of novel contrast agents for MRI.
Now a singer/songwriter, Web-page: www.paulgoodwin.com. [Photo]

Andrew Thomson. Ph.D. student, Oct 2000-2004. Examined 12th August 2004.
Ph.D. project: Synthesis of Macrocyclic Thiazolium Salts as models for thiamin pyrophosphate-dependent enzymes.
E-mail address: act38@cam.ac.uk [
Photo]

Katharine Collis and Siri Kumarn were Part III project students, Oct 2003-March 2004, both from St Catherine's College.
Projects: Synthesis of Thiamin Diphosphate Analogues. and Synthesis of Intermediates in Prodigiosin Biosynthesis.
[
Photo]

Boon-Jong Tan was a M.Phil. student, Oct 2002-Sept 2003.
M.Phil. project: Synthesis of deazathiamin pyrophosphate derivatives
E-mail address: boonculi@singnet.com.sg [
Photo]

Max Khan was a summer student July-Aug 2003.

Catherine Goodwin was a Ph.D. student, Oct 1999-2003. Examined 3rd July 2003. Her Ph.D. project was Mechanistic studies on ALA dehydratase. She started work for Evotec OAI, a contract synthesis company near Oxford in 2004.
E-mail address: goodwin_ce@yahoo.co.uk [
Photo]

Stéphane Mann was a Post-doc, May 2002-July 2003.
Project: Analogues of thiamin diphosphate and their interaction with TPP-dependent enzymes.
Previously Ph.D. student with Prof. A. Marquet in Paris. Now has a CRNS research position at the Université Pierre et Marie Curie in Paris. E-mail address: mann@ccr.jussieu.fr (as of 22/9/03) [
Photo]

Raef Ahmed was a Ph.D. student from Palestine, starting Oct 1998, who was examined 25/7/02 and left in September 2002. His Ph.D. thesis was on Synthesis of analogues of PBG and studies of their effect on PBG deaminase. He started a post-doc with Martin Tanner at UBC in Canada in 2002. Subsequently a post-doc with Ben Davis in Oxford. E-mail address: raef192000@yahoo.co.uk (as of 23/1/03) [Photo]

D. Hawksley was a PhD student who worked on Synthesis and Evaluation of Thiamin Diphosphate Analogues and left in March 2002. He worked first as a Research Analyst for Oakland Innovation and Information Services and then moved in summer 2002 to Arqule on the Cambridge Science Park as a Lead Optimisation scientist in drug discovery. Married Louise, April 7th 2001. E-mail address: DHawksley@arqule.com (as of 14/10/02) [Photo]

Concha Perez-Melero. Post-doc, Oct 1999-Oct 2001. Project: Analogues of thiamin diphosphate and their interaction with TPP-dependent enzymes. Now returned to the University of Salamanca in Spain to take up a lectureship. E-mail address: conchapm@usal.es [Photo]

Whole Group
The whole group October 2000

Martin Schüler was an ERASMUS student from the University of Hannover Oct 1998-March 1999. He worked on the Synthesis of a chiral macrocyclic thiazolium salt. After leaving Cambridge he returned to Hannover, completing his Diploma in January 2002. He plans to start a Ph.D. with Prof. David O«Hagan at St.Andrews University in October 2002.

Marcus J. White was a PhD student who worked on Synthesis and reactions of macrocyclic thiazolium salts and left in 2001. He did postdoctoral research with Prof Francois Mathey at the Ecole Polytechnique in Paris and then Prof. E. Gössinger in Vienna. In 2004 he joined Georg Thieme Verlag KG where he is a Scientific Editor. E-mail address: marcusjwhite@yahoo.co.uk (as of 30/11/01) marcus.white@thieme.de (as of 13/11/07) [Photo]

Roland L. Knight was a PhD student who worked on Chiral Thiazolium Salts for Asymmetric C-C Bond Formation and left in April 1998. He is working for Celltech Chiroscience's facility at Granta Park, Abington. E-mail address: Roland.Knight@cam.celltechgroup.com (as of 8/1/2003)

A. Ulrich Gerhard was a Ph.D. student who worked on Chiral Thiazolium Salts for Asymmetric C-C Bond Formation and left in April 1997. He is now working at the Gulf International Bank (UK) Ltd, One Knightsbridge, London SW1 7XS (tel. 0207 259 3430) as an analyst of the chemical industry. E-mail address: Uli.Gerhard@gibuk.com (as of 2/4/02). Married to Yvonne with one baby daughter (Ursula b. 2nd April 2003) [Photos: Uli, Yvonne]. Home Address: 22 Bearton Road, Hitchin, SG5 1UB (tel. 01462-452913).

Stephen P. Walcot M.Phil. student (1995-96), Use of Polymeric Reagents in Synthesis

Yongfu Li Post-doc (Oct 1995-Sept 1996), Tetrapyrrole Enzyme Stereochemistry

Stephen P. Langston Post-doc (Oct 1995-May 1996), Synthesis of Doubly Modified Adenosine Analogues. Working for Peptide Therapeutics on the Cambridge Science Park.

Conchi Gonzalez Bello (1994-95) Post-doc jointly with Chris Abell (Oct 1994-Sept 1995), Catalytic Antibodies for Cationic Cyclisations. Subsequently post-doc for Chris Abell. Now lecturer at University of Santiago di Compostella in Spain. E-mail address: cgb1@lugo.usc.es (as of 1/8/00)

Alexei A. Yeliseev Visiting Post-doc sponsored by Royal Society 1993, Enzymic and Genetic Studies on Vitamin B12 Biosynthesis. Originally from A.N. Bakh Institute of Biochemistry, Russian Academy of Sciences, 117071 Moscow, Russia. Subsequently held various positions in US universities. Now Senior Scientist, Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, CA 94545, E-mail address: yeliseev@kosan.com (as of 4/9/01)

Alfredo. Capretta Post-doc funded by Prof. A.R. Battersby 1992-94, Absolute Configuration of Chiral Pyrrolylmethyl Lactams. Now lecturer at Brock University, Ontario, Canada. E-mail address: fcaprett@chemiris.labs.BrockU.CA (as of 2/1/02)

Nigel J. Jones Ph.D. student (1992-96), Asymmetric Induction Catalysed by Chiral Thiazolium Salts.

Diana Appleton Ph.D. student (1992-95) Inhibition and Mechanistic Studies on ALA Dehydratase. Left in 1996 to take up teaching at School in Glasgow. Married to Gary Smith. Daughter, Emily Claire Smith, born Jan 2000. E-mail address: gds@gsmith35.fsnet.co.uk (as of 14/1/00)

Chris Lawrence Ph.D. student (1991-1994), Monoclonal Antibodies to Catalyse Cationic Cyclizations. Taught chemistry at Christ's Hospital School.

Steve Howard Ph.D. student (1991-1994), Synthesis of Polyhydroxy Indolizidines. Left in 1995 to post-doc with Steve Withers at Univ. British Columbia, Vancouver. Returned to a medicinal chemistry job at SmithKline Beecham in Harlow (subsequently Glaxo SmithKline). Now working for Astex on the Cambridge Science Park. E-mail address: steven.howard0@talk21.com (as of 9/3/02) and s.howard@astex-therapeutics.com

Prashant Savle Ph.D. student (1990-1993), Thiazolium Salts as Thiamin Models. Went to post-doc in US for Richard Gandour at Virginia Polytech Inst & State Univ. E-mail address: prashant@irisdav.chem.vt.edu (as of 20/3/97)

Karen E. Holt Ph.D. student (1990-1993), Stereospecific Synthesis of Enzyme Inhibitors using Aldolase.. Worked at Chiroscience on the Science Park.

Wing H. Chia Ph.D. student (1989-1992), Catalytic Antibodies for Oligosaccharide Hydrolysis.

Susan Shaw Ph.D. student (1989-1992), Biosynthesis of the Indolizidine Alkaloid Cyclizidine.

Ian M. Bell Ph.D. student (1988-1991), Monoclonal Antibodies as Catalysts for Cationic Cyclizations. Now at Merck in the U.S. E-mail address: (as of ) [Photo]

Martin Rock Ph.D. student (1986-1989) (1990), Modified Substrates for Tetrapyrrole Biosynthesis. Consultant for Chemsystems E-mail address: MartinRock@chemsystems.co.uk (as of 28/4/97)

Padma Padmanabhan (now Satish) Ph.D. student (1985-1988), Biosynthesis of the Indolizidine Alkaloid Cyclizidine. Technical Officer at the Dean of R&D Office in Indian Institute of Tech. Bombay. Married to Satish, two daughters - Pratima (b. 1991/2) and Srinidhi (b. 1995) E-mail address: OPADMA@ganga.admin.iitb.ernet.in (as of 24/12/98)

Dave H. C. Smith Ph.D. student (1984-1987), Thiazolium Salts as Thiamin Models. Worked for ICI Paints, then as a computer consultant for a smallish firm called Axon, based in Twickenham. Married to Su, children Katie (1995) and Sam (1996/7) E-mail address: DavidHCSmith@compuserve.com (as of 25/12/97)

   

Department of Chemistry
University of Cambridge