Leeper Group



inhibitor structure113
Karl M. Erixon, Chester L. Dabalos and Finian Leeper, "Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics." Chem. Comm., 2007, 960-962. Full Text

Replacement of the thiazolium ring of thiamine pyrophosphate with a triazole gives extremely potent inhibitors of pyruvate decarboxylase from Z. mobilis, with KI values down to 20 pM; this system was used to explore pyrophosphate mimics and several effective analogues were discovered.

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Department of Chemistry
University of Cambridge