Leeper Group



Interactions of 2-HEdeazaTPP with DXPS André A. Neves, Yéléna A. Wainman, Alan Wright, Mikko I. Kettunen, Tiago B. Rodrigues, Sarah McGuire, De-En Hu, Flaviu Bulat, Simonetta Geninatti Crich, Henning Stöckmann, Finian J. Leeper, Kevin M. Brindle,
"Imaging glycosylation in vivo using metabolic labeling and MRI"
Angew. Chem. Int. Ed., 2016, 55 (4), 1286-1290. Abstract, Full Text.

Lighting up cell surface glycans with MRI: Glycans were imaged in live mice using MRI, following metabolic labeling with an azido-labeled sugar and subsequent administration of a strained cyclooctyne TMDIBO linked to a gadolinium contrast agent. Azido-sugar-dependent contrast was observed in various tissues including tumor, kidney, spleen, gut and liver, 2 hours after contrast agent administration. Since cell surface glycosylation is often aberrant in cancer and other diseases, this approach may enable non-invasive imaging of disease progression.

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Department of Chemistry
University of Cambridge