Leeper Group



Y. Li, A. I. D. Alanine, S. Balachandran, R. A. Vishwakarma, F. J. Leeper and A. R. Battersby
"Biosynthesis of Vitamin B12: Mechanistic Studies on the Transfer of a Methyl Group from C-11 to C-12 and Incorporation of 18O"
J. Chem. Soc., Chem. Commun., 1994, 2507-2508. Full Text

The transfer of a methyl group from C-11 to C-12 in vitamin B12 biosynthesis is shown, by a crossover experiment involving [1,11,17- (CD3)3]-labelled precursors, to occur in an intramolecular fashion; it is found that in Pseudomonas denitrificans, unlike Propionibacterium shermanii, no exchange of the ring A acetate oxygen atoms occurs during formation of the corrin ring.

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Department of Chemistry
University of Cambridge