Leeper Group



A. C. Spivey, A. Capretta, C. S. Frampton, F. J. Leeper and A. R. Battersby
"Stereochemical Studies on the Proposed Spiro Intermediate for the Biosynthesis of the Natural Porphyrins: Determination by a Novel X-Ray Method of the Absolute Configuration of the Spirolactam which Inhibits Cosynthetase"
J. Chem. Soc., Chem. Commun.,1995, 1789-1790. Full Text

A novel X-ray analysis, combined with correlations by circular dichroism, has been used to establish the R-configuration at the stereocentre in that enantiomer of the spirolactam which strongly inhibits uroporphyrinogen III synthase.

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Department of Chemistry
University of Cambridge