Leeper Group



F. J. Leeper and S. Howard
"Stereocontrolled Syntheses of Polyhydroxy Indolizidines, Including 8a-Epi, 6,8a-Diepi and 1,6-Diepi-castanospermine, Starting from Malic Acid"
Tetrahedron Lett.,1995, 36, 2335-2338. Full Text

Stereocontrolled total syntheses of one trihydroxy indolizidine and three tetrahydroxy indolizidines - all diastereoisomers of castanospermine - are described which use malic acid as the only chiral starting material.

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Department of Chemistry
University of Cambridge