Leeper Group



G. W. Weaver, F. Blanche, D. Thibaut, L. Debussche, F. J. Leeper and A. R. Battersby
"Biosynthesis of Vitamin B12: Incorporation of 11S-[11-2H]- and 11R-[11-2H]-Porphobilinogen into Sirohydrochlorin and 2,7,20-Trimethylisobacteriochlorin"
J. Chem. Soc., Chem. Commun.,1990, 1125-27.

(11S)-[2H1]Porphobilinogen (1a) and the (11R)-isomer (1b) are incorporated biosynthetically into precorrin-2 and precorrin-3 which are isolated as the aromatised esters (7) and (9) for 1H NMR studies; the unexpected results are discussed.

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Department of Chemistry
University of Cambridge