Leeper Group



F. J. Leeper and D. H. C. Smith
"The Effect of Strain on the Catalytic Reactions of Bridged Thiazolium Salts as Models of Thiamin"
J. Chem. Soc., Chem. Commun.,1990, 961-963. Full Text

The reactivity of bridged thiazolium salts (9) and (10) has been studied; the model (9) with the shorter bridge is unable to catalyse the benzoin condensation reaction and it was shown that this is due to failure of the condensation step (5) -> (6), probably owing to the effects of strain.

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Department of Chemistry
University of Cambridge