Leeper Group



G. J. Hart, A. D. Miller, F. J. Leeper and A. R. Battersby
"Biosynthesis of the Natural Porphyrins: Proof that Hydroxymethylbilane Synthase (Porphobilinogen Deaminase) uses a Novel Binding Group in its Catalytic Action"
J. Chem. Soc., Chem. Commun., 1987, 1762-1764. Full Text

Hydroxymethylbilane synthase builds a bilane by assembling 4 monopyrrolic units, the first of these being bound covalently to the enzyme through a group X; it is proved that X represents a unique enzymic cofactor based on a pyrromethane system.

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Department of Chemistry
University of Cambridge