Leeper Group



F. J. Leeper, P. Padmanabhan, G. W. Kirby and G. N. Sheldrake
"Biosynthesis of the Indolizidine Alkaloid, Cyclizidine"
J. Chem. Soc., Chem. Commun., 1987, 505-506. Full Text

The 1H and 13C n.m.r. spectra of cyclizidine (1) have been completely assigned and incorporation experiments with 13C-labelled sodium acetate and propionate and sodium [3-2H3]propionate have revealed that the entire carbon skeleton of (1) is derived from these precursors by a polyketide-type biosynthetic pathway, with the cyclopropyl ring being derived from a single propionate unit.

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Department of Chemistry
University of Cambridge