Leeper Group

   

Abstract

99
R. L. Knight and F. J. Leeper
"Comparison of chiral thiazolium and triazolium salts as asymmetric catalysts for the benzoin condensation"
J. Chem. Soc., Perkin Trans. 1,1998, 1891-1893. Full Text

Chiral bicyclic 1,2,4-triazolium salts having a defined face of the heterocyclic ring hindered have been synthesised and they catalyse the benzoin condensation in good yield; the enantiomeric excesses obtained (up to 80%) are much better than with closely related thiazolium salts and the opposite enantiomer of benzoin predominates.

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Department of Chemistry
University of Cambridge