Leeper Group



Labelling strategy Yéléna A. Wainman, André A. Neves, Shaun Stairs, Henning Stöckmann, Heather Ireland-Zecchini, Kevin M. Brindle and Finian J. Leeper,
"Dual-sugar imaging using isonitrile and azido-based click chemistries"
Org. Biomol. Chem., 2013, 11 (42), 7297-7300. Accepted manuscript, Full Text.

We report the first account of metabolically labelling N-acetylglucosamine, in conjunction with either N-acetylgalactosamine or N-acetylmannosamine using a combination of isonitrile- and azide-based chemistries. With the appropriately labelled fluorescent probe molecules, that react with either the azido or isonitrile groups, the method enabled co-visualisation of cancer cell glycoproteins.

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Department of Chemistry
University of Cambridge