Abstract

136
Helen L. Evans, Rozanna L. Slade, Laurence Carroll, Graham Smith, Quang-De Nguyen, Lisa Iddon, Nazilla Kamaly, Henning Stöckmann, Finian J. Leeper, Eric O. Aboagye and Alan C. Spivey,
"Copper-free Click – A Promising Tool for Pre-Targeted PET Imaging"
Chem. Comm., 2012, 48 (7), 991-993. Full Text.

The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [¹⁸F]2-fluoroethylazide ([¹⁸F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.

Previous abstract

Next abstract