Leeper Group



Non-hydrolysable SNAC ester analogues Manuela Tosin, Yuliya Demydchuk, James S Parascandolo, Covadonga Blasco Per, Finian J Leeper and Peter F Leadlay "In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines" Chem. Comm., 2011, 47 (12), 3460-2. Full Text.

Early-stage intermediates in the biosynthesis of erythromycin A by Saccharopolyspora erythraea were intercepted by malonyl carba(dethia)-N-acetyl cysteamines, generated in vivo from the hydrolysis of the corresponding methyl esters.

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Department of Chemistry
University of Cambridge