Abstract

15
F. J. Leeper and J. Staunton
"The Biosynthesis of Rubrofusarin, a Polyketide Naphthopyrone from Fusarium culmorum: ¹³C NMR Assignments and Incorporation of ¹³C and ²H-Labelled Acetates"
J. Chem. Soc., Perkin Trans. 1,1984, 2919-2925. Full Text

The polyketide chain in rubrofusarin biosynthesis has been shown to adopt the folding pattern B by the incorporation of ¹³CH₃¹³CO₂Na and of CD₃¹³CO₂Na, with observation of the b-isotopic shifts in the ¹³C n.m.r. spectrum, in the rubrofusarin derivative (5). The extent of retention of deuterium at the various sites is interpreted in terms of an unusual sequence of biosynthetic steps. The assignment of the ¹³C n.m.r. spectrum of rubrofusarin dimethyl ether (2) was made with the aid of specific deuteriation and ¹H-¹³C n.O.e.'s as well as more standard techniques.

Previous abstract

Next abstract