Syntheses of 6-methoxy-1-methyl-1,2,3,4-tetrahydroquinoline-3-methanol and 1,2,3,5,6,10b-hexahydrobenzo[g]indolizine-6-methanol are described. The aryl phosphonic acid, which can be used as a linker to a protein, is synthesised and coupled to the above alcohols. These haptens, when linked to a protein, are intended to generate antibodies able to catalyse cationic cyclisation reactions.
Department of Chemistry
University of Cambridge