Leeper Group



C. Gonzalez Bello, C. Abell and F. J. Leeper
"Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies"
J. Chem. Soc., Perkin Trans. 1,1997, 1017-1024. Full Text

Syntheses of 6-methoxy-1-methyl-1,2,3,4-tetrahydroquinoline-3-methanol and 1,2,3,5,6,10b-hexahydrobenzo[g]indolizine-6-methanol are described. The aryl phosphonic acid, which can be used as a linker to a protein, is synthesised and coupled to the above alcohols. These haptens, when linked to a protein, are intended to generate antibodies able to catalyse cationic cyclisation reactions.

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Department of Chemistry
University of Cambridge