Leeper Group



R. L. Knight and F. J. Leeper
"Synthesis of and Asymmetric Induction by Chiral Bicyclic Thiazolium Salts"
Tetrahedron Lett.,1997, 38, 3611-3614. Full Text

Three different chiral bicyclic thiazolium salts have been synthesised in enantiomerically pure form. These salts all catalysed the formation of benzoin and butyroin from benzaldehyde and butyraldehyde respectively and the product had the R-configuration in each case with e.e.'s in the range 10-33%. Possible reasons for these results are discussed.

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Department of Chemistry
University of Cambridge