Leeper Group



C. Abell, M. J. Garson, F. J. Leeper and J. Staunton
"Biosynthesis of Fungal Metabolites, Alternariol, Mellein, Rubrofusarin and 6-Methylsalicylic Acid from CD3CO2H"
J. Chem. Soc., Chem. Commun.,1982, 1011-1013. Full Text

The pattern of incorporation of deuterium from CD3CO2H into the fungal metabolites alternariol, mellein, rubrofusarin, and 6-methylsalicylic acid has been determined by 2H n.m.r. spectroscopy; the results are interpreted in terms of a proposed mode of action for polyketide synthases.

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Department of Chemistry
University of Cambridge