Abstract

17
D. M. Doddrell, E. D. Laue, F. J. Leeper, J. Staunton, A. Davies, A. B. Davies and G. A. F. Ritchie
"Biosynthesis of the Polyether Antibiotic ICI 139603 in Streptomyces longisporoflavus: Investigation of Deuterium Retention after Incorporation of CD₃¹³CO₂H, ¹³CD₃CO₂H, and CH₃CD₂¹³CO₂H using ²H NMR and edited ¹³C NMR Spectra"
J. Chem. Soc., Chem. Commun.,1984, 1302-1304. Full Text

The mechanism of carbocyclic ring formation in the biosynthesis of the polyether antibiotic ICI139603 (2) was investigated by deuterium retention studies after incorporation of CD₃¹³CO₂H, ¹³CD₃CO₂H, and CH₃CD₂¹³CO₂H using ²H n.m.r. spectroscopy, a- and b-isotopic shifts, and edited ¹³C n.m.r. spectroscopy.

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