Leeper Group



R. D. Brunt, F. J. Leeper, I. Grgurina and A. R. Battersby
"Biosynthesis of Vitamin B12: Synthesis of ()-[5-13C]Faktor-1 Ester: Determination of the Oxidation State of Precorrin-1"
J. Chem. Soc., Chem. Commun.,1989, 428-431. Full Text

(+)-[5-13C]Faktor-l ester is synthesised following an east-west disconnection strategy and is used to show by specific enzymic incorporation experiments that the first C-methylation product, precorrin-1, on the B12-biosynthetic pathway is a tetrahydrochlorin.

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Department of Chemistry
University of Cambridge