Leeper Group



M. H. Block, S. C. Zimmerman, G. B. Henderson, S. P. D. Turner, S. W. Westwood, F. J. Leeper and A. R. Battersby
"Syntheses Relevant to Vitamin B12 Biosynthesis: Synthesis of Sirohydrochlorin and of its Octamethyl Ester"
J. Chem. Soc., Chem. Commun., 1985, 1061-1063. Full Text

Sirohydrochlorin is an isobacteriochlorin isolated (a) as the metal-free prosthetic group of sulphite reductase and (b) as the aromatised form of the di-C-methylated intermediate on the biosynthetic pathway to vitamin B12; the synthesis is described of the natural enantiomer of sirohydrochlorin and also of its octamethyl ester using a mild photochemical route.

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Department of Chemistry
University of Cambridge