Abstract

20
M. H. Block, S. C. Zimmerman, G. B. Henderson, S. P. D. Turner, S. W. Westwood, F. J. Leeper and A. R. Battersby
"Syntheses Relevant to Vitamin B₁₂ Biosynthesis: Synthesis of Sirohydrochlorin and of its Octamethyl Ester"
J. Chem. Soc., Chem. Commun., 1985, 1061-1063. Full Text

Sirohydrochlorin is an isobacteriochlorin isolated (a) as the metal-free prosthetic group of sulphite reductase and (b) as the aromatised form of the di-C-methylated intermediate on the biosynthetic pathway to vitamin B₁₂; the synthesis is described of the natural enantiomer of sirohydrochlorin and also of its octamethyl ester using a mild photochemical route.

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