Suresh R. Chawrai, Neil R. Williamson, George P. C. Salmond and Finian J. Leeper, "Chemoenzymatic synthesis of prodigiosin analogues – exploring the substrate specificity of PigC." Chem. Commun., 2008, 1862–1864. Full Text.
Analogues of prodigiosin, a tripyrrolic pigment produced by Serratia species with potent immunosuppressive and anticancer activities, have been produced by feeding synthetic analogues of the normal precursor MBC to mutants of Serratia sp. ATCC 39006 or to engineered strains of Escherichia coli; in this way it has been shown that the prodigiosin synthesising enzyme, Pig C, has a relaxed substrate-specificity.
Department of Chemistry
University of Cambridge