Leeper Group



D. Appleton and F. J. Leeper
"Mechanism-based Inhibition of 5-Aminolaevulinic Acid Dehydratase from Bacillus subtilis by the 3-Thia Analogue of the Substrate"
Chem. Commun.,1996, 303-304. Full Text

The interaction of various substrate analogues with 5-aminolaevulinic acid dehydratase (porphobilinogen synthase) from Bacillus subtilis has been studied kinetically and by electrospray mass spectrometry; 5-chlorolaevulinic acid has been shown to be a non-specific alkylating agent but 5-amino-3-thialaevulinic acid is a potent mechanism-based inactivator.

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Department of Chemistry
University of Cambridge