M. Kodera, F. J. Leeper and A. R. Battersby
"Biosynthesis of Vitamin B12: The Fate of H-8 as Precorrin-2 is Enzymically Converted into Cobyrinic Acid"
J. Chem. Soc., Chem. Commun.,1992, 835-837. Full Text
The dimethylated B12-Precursor, precorrin-2, is prepared strongly labelled with tritium at 3-H and 8-H to allow proof that the 3-H label is retained where as the 8-H label is lost during the biosynthetic conversion of precorrin-2 into cobyrinic acid.
Department of Chemistry
University of Cambridge