F. J. Leeper and M. Rock
"Modified Substrates for Tetrapyrrole Biosynthesis: Analogues of Porphobilinogen Showing Unusual Inhibition of Porphobilinogen Deaminase"
J. Chem. Soc., Chem. Commun.,1992, 242-244. Full Text
Syntheses are described of two analogues of porphobilinogen (PBG), a fluoro derivative and a phosphonate, which are the first known unnatural substrates of PBG deaminase; when they act as inhibitors of the reaction of PBG, these compounds produce unusual sigmoidal kinetics, explained by their involvement as poor substrates in the particular mechanism of this enzyme.
Department of Chemistry
University of Cambridge