Leeper Group



F. J. Leeper and M. Rock
"Modified Substrates for Tetrapyrrole Biosynthesis: Analogues of Porphobilinogen Showing Unusual Inhibition of Porphobilinogen Deaminase"
J. Chem. Soc., Chem. Commun.,1992, 242-244. Full Text

Syntheses are described of two analogues of porphobilinogen (PBG), a fluoro derivative and a phosphonate, which are the first known unnatural substrates of PBG deaminase; when they act as inhibitors of the reaction of PBG, these compounds produce unusual sigmoidal kinetics, explained by their involvement as poor substrates in the particular mechanism of this enzyme.

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Department of Chemistry
University of Cambridge