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Abstract 53
F. Kiuchi, D. Thibaut, L. Debussche, F. J. Leeper, F. Blanche and A. R. Battersby "Biosynthesis of Vitamin B12: Stereochemistry of Transfer of a Hydride Equivalent from NADPH by Precorrin-6x Reductase" J. Chem. Soc., Chem. Commun.,1992, 306-308. Full Text Deuterium labelling with NMR analysis demonstrates that the enzyme precorrin-6x reductase transfers HR from C-4 of the pyridine residue of NADPH as the first step in the sequence leading from precorrin-6x to hydrogenobyrinic acid.
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