F. J. Leeper and M. Rock
"Synthesis of a Fluorinated Analogue of 5-Aminolaevulinic Acid, a Potential Inhibitor of Porphyrin Biosynthesis"
J. Fluor. Chem.,1991, 51, 381-396. Full Text
5-Amino-2-fluorolaevulinic acid 3 has been synthesized in high yield by modification of a new route to 5-aminolaevulinic acid (ALA), involving gamma-lactone intermediates. Initial studies suggest that 3 is an inhibitor of ALA dehydratase, an early enzyme of tetrapyrrole biosynthesis.
Department of Chemistry
University of Cambridge