Leeper Group



R. Ahmed and F. J. Leeper
"A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase."
Org. Biomolec. Chem.,, 2003, 1, 21-23. Full Text

Two analogues of porphobilinogen, the 6-methyl and 6,11-ethano derivatives, have been made by a new synthetic route and the 6-methyl analogue has proved to be the most potent inhibitor of hydroxymethylbilane synthase yet reported (Ki = 3 mM).

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Department of Chemistry
University of Cambridge