Leeper Group



Maxime Couturier, Hiral D. Bhalara, Rita E. Monson, George P. C. Salmond and Finian J. Leeper
"Revision in the first steps of the biosynthesis of the red antibiotic prodigiosin: use of a synthetic thioester to validate a new intermediate"
RSC Chem. Biol., 2021, 2 (2), 551-555. Full text

A biosynthetic pathway for the red-antibiotic, prodigiosin, was proposed over a decade ago but not all the suggested intermediates could be detected experimentally. Here we show that a thioester that was not originally included in the pathway is an intermediate. In addition, the enzyme PigE was originally described as a transaminase but we present evidence that it also catalyses the reduction of the thioester intermediate to its aldehyde substrate.

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Department of Chemistry
University of Cambridge