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Abstract 67
K. E. Holt, F. J. Leeper and S. Handa "Synthesis of beta-1-Homonojirimycin and beta-1-Homomannojirimycin using the Enzyme Aldolase" J. Chem. Soc., Perkin Trans.1,1994, 231-234. Full Text The four stereoisomers of the four-carbon azido sugar 11 have been stereoselectively synthesised by a route involving Sharpless epoxidation and all are found to be substrates for rabbit muscle fructose 1,6-bisphosphate aldolase, giving (after treatment with phosphatase) 6-azido-6-deoxyheptuloses 14; hydrogenation of 14a and 14b gave beta-1-homomannojirimycin 15a and beta-1-homonojirimycin 15b with high selectivity.
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