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Abstract 49 M. A. Cassidy, N. Crockett, F. J. Leeper and A. R. Battersby "Synthetic Studies on the Proposed Spiro Intermediate for Biosynthesis of the Natural Porphyrins: The Stereochemical Probe" J. Chem. Soc., Chem. Commun.,1991, 384-386. The intermediacy of the spiro-pyrrolenine for biosynthesis of uro'gen III is supported by synthesis of both enantiomers of the spiro-lactam followed by demonstration that cosynthetase, the enzyme which forms uro'gen III, is inhibited over twenty times more strongly by one enantiomer than by the other.
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