Leeper Group



F. Blanche, S. Handa, D. Thibaut, C. L. Gibson, F. J. Leeper and A. R. Battersby
"Biosynthesis of Vitamin B12: When is the 12b-Methyl Group of the Vitamin Generated by Acetate Decarboxylation?"
J. Chem. Soc., Chem. Commun.,1988, 1117-1119. Full Text

The 12-methyl analogue (13) of the aromatised form of precorrin-3 (5) has been prepared by enzymic C-methylation of 12-decarboxy-uro’gen-Ill (2) and is used for incorporation experiments which indicate that decarboxylation of the 12-acetate residue in B12-biosynthesis occurs after C-17 methylation.

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Department of Chemistry
University of Cambridge