Leeper Group



F. J. Leeper, M. Rock and D. Appleton
"Synthesis of Analogues of Porphobilinogen"
J. Chem. Soc., Perkin Trans. 1,1996, 2633-2642. Full Text

Syntheses are described of several analogues of porphobilinogen intended as substrates and/or inhibitors of porphobilinogen deaminase (hydroxymethylbilane synthase). 2-Methylporphobilinogen was synthesised from 2-methylpyrrole, whereas a phosphonate analogue of porphobilinogen, 8,9-dehydroporphobilinogen and 9-fluoroporphobilinogen were all made from the azaindole. The best route to avoided fluoroacrylate because of loss of fluorine during reduction of the double bond.

Previous abstract Next abstract


Department of Chemistry
University of Cambridge