Leeper Group



F. J. Leeper and P. N. Lowe
"The Stereochemistry and Conformation of the Diastereomers of Tetrahydrothiamin"
Heterocycles,1983, 20, 65-68. Full Text

The major isomer of tetrahydrothiamin produced by NaBH4 reduction of thiamin is shown by 1H n.m.r. to be cis (5) and its conformation is predominantly (5a) which should be a major factor in the strong inhibition shown by its pyrophosphate (2) towards the pyruvate dehydrogenase complex af E.coli.

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Department of Chemistry
University of Cambridge